Early mobilization and quality of life after stroke: Findings from AVERT

TB Cumming; L Churilov; J Collier; G Donnan; F Ellery; H Dewey; P Langhorne; RI Lindley; M Moodie; AG Thrift; J Bernhardt

Journal article

Early mobilization and quality of life after stroke: Findings from AVERT

TB Cumming, L Churilov, J Collier, G Donnan, F Ellery, H Dewey, P Langhorne, RI Lindley, M Moodie, AG Thrift, J Bernhardt

Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

DOI: 10.1212/WNL.0000000000007937

Abstract

ObjectiveTo determine whether early and more frequent mobilization after stroke affects health-related quality of life.MethodsA Very Early Rehabilitation Trial (AVERT) was an international, multicenter (56 sites), phase 3 randomized controlled trial, spanning 2006-2015. People were included if they were aged ≥18 years, presented within 24 hours of a first or recurrent stroke (ischemic or hemorrhagic), and satisfied preordained physiologic criteria. Participants were randomized to usual care alone or very early and more frequent mobilization in addition to usual care. Quality of life at 12 months was a prespecified secondary outcome, evaluated using the Assessment of Quality of Life 4D (AQoL-..

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University of Melbourne Researchers

Leonid Churilov Author

Geoffrey Donnan Author

Julie Bernhardt Author

Stephen Davis Author

Related Projects (2)

AVERT: A large, international, randomised controlled trial testing efficacy and cost effectiveness of early and frequent mobilisation after stroke

AVERT is a large, international clinical trial that tests whether introducing early and frequent exercise helps reduce the unacceptably high..

RESEARCH FELLOWSHIP

Stroke affects 1 in 6 Australians and often leads to lifelong disability. This Fellowship will support A/Prof Bernhardt to: 1) complete the ..

Grants

Awarded by National Health Research Institutes

Funding Acknowledgements

The trial was initially supported by the National Health and Medical Research Council (NHMRC) of Australia (grants 386201, 1041401). Additional funding was received from Chest Heart and Stroke Scotland (Res08/A114), Northern Ireland Chest Heart and Stroke, Singapore Health (SHF/FG401P/2008), the UK Stroke Association (TSA2009/09), and the UK National Institute of Health Research (HTA Project 12/01/16). NHMRC fellowship funding was provided to A.G.T. (1042600), H.D. (336102), and J.B. (1058635). J.B. also received fellowship funding from the Australia Research Council (0991086) and the National Heart Foundation.